Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity

Document Type : Original Article

Authors

1 - Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt

2 Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt

3 Department of water pollution, National Research Center, Dokki, Cairo, Egypt

4 Department of Photochemistry, National Research Center, Dokki,Cairo, Egypt

Abstract

Thirteen chemical compounds belonging to the fused heterocyclic pyrimidines were synthesized and screened in order to assay their antiviral activity against the avian influenza virus (H5N1) A/Chicken/Qalubiya/1/2006(H5N1) by plaque reduction assay on MDCK cells. All tested compounds were non-toxic on the cells. Ten out of thirteen compounds (10, 13, 9, 12, 1, 11, 7, 8, 3 and 4) showed moderate percentage of inhibition respectively at concentration 20 μg/ml while the remaining three compounds (5, 2 and 6) showed weak inhibitory activity respectively at same concentration.

Keywords