Impact of synthetic detergent on sporicidal activity in pharmaceutical facility

Document Type : Original Article

Authors

1 Department of Microbiological Quality Control, Hikma Pharm Pharmaceutical Company, 6th October City, Giza, Egypt

2 Department of Microbiology & Immunology, Faculty of Pharmacy October University, 6th October City, Egypt.

3 Department of Microbiology & Immunology, Faculty of Pharmacy (Boys), Al-Azhar University, Cairo, Egypt

Abstract

A continuous validation programs for disinfectants are very important in controlling microbial bioburden of environmentally controlled area. Carrier test was chosen because it is more challenging than the usual suspension test. Materials used represent floor, wall, and stainless steel surfaces. This experiment showed that detergents such as sodium dodecyl sulphate improved sporicidal effect on microorganisms even with those who demonstrated relatively high resistance to the used antimicrobial. The used surfactant enhanced the sporicidal activity within five minutes contact time with most commonly found Bacillus speciesin the pharmaceutical facility. However, Bacillus licheniformis spores showed greatest tolerance among studied environmental isolates. 

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