Comparison between Haemagglutination Inhibition and Complement Fixation Tests in Detecting Antibodies Responses Following Influenza Viral Infection

Document Type : Original Article

Author

Medical Microbiology, Microbiol. Dept. Virology, College of Medicine, Univ. Anbar

Abstract

Objectives: To evaluate sensitivity and specificity of HI and CF tests for detecting antibody responses following naturally occurring influenza A and B infections.
Methods: One hundred and twenty blood samples were drawn from one hundred patients with flue-like illness and twenty apparently healthy control subjects and tested at Central Health Laboratory in Baghdad/ Iraq using HI and CF tests for detecting three currently circulating influenza A and B strains during the period from the 1st of January 2008 to the 1st of June 2009.                                                 
Results: 78-80% of the patients with flu-like illness responded to a t least one of three influenza virus antigens as measured by HI, while 34-35% of those patients showed a response by CF test.
Conclusions: HI test has a higher sensitivity and lower specificity than CF test for detecting antibody responses from patients with influenza A and B viral infections.

Keywords

Egyptian Academic Journal of Biological Sciences, G. Microbiology
Volume 4, Issue 1
December 2012
Pages 35-38

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