Evaluation of Some Biological Activities of Phialosimplex asmahalo

Document Type : Original Article

Author

Botany and Microbiology Department, Faculty of Science (Girls), Al-Azhar University, Nasr City, Cairo, Egypt

Abstract

Phialosimplex asmahalo is an obligate halophilic fungus that requires at least 5 % (w/v) sodium chloride for growth.  It was previously isolated and identified. The ethyl acetate extract ofPhialosimplex asmahalo was fractionated and three compounds 1, 3, and 6 were purified. In this studypure compounds of Phialosimplex asmahalo were evaluated for their anti-diabetes, anti-inflammatory, antiviral and hepatoprotective activities. Compounds 3 and 6 have anti-diabetic activities with IC50 47.03 and 82.3 respectively; whereas compound 1 has no anti-diabetic activity. Compounds 3 and 6 have anti-inflammatory activities with IC50 125 and 294 respectively; whereas compound 1 has no anti-inflammatory activity. Compound 3 has antiviral activity against Hepatitis A virus and Herpes Simplex type 1 virus in a percentage of 24.7 and 10.2 respectively. Compound 6 has antiviral activity against Hepatitis A only with a percentage of 11.3. Compound 1 has no antiviral activity against Hepatitis A virus and Herpes Simplex type 1 virus. Compounds 1 and 3 have hepatoprotective activities percentage 7.1 and 23.6 respectively; whereas compound 6 has no hepatoprotective activity. 

Keywords

Egyptian Academic Journal of Biological Sciences, G. Microbiology
Volume 12, Issue 2
December 2020
Pages 9-19

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