The Antibacterial Activity Of Bee Venom On Selected Pathogenic Bacteria

Salem, Amany Z.; Bedair, El-Sayed H.; Hablas, Wael R.; Elfiky, Abir A.; Hussein, Basma I.

doi:10.21608/eajbsg.2015.16487

The Antibacterial Activity Of Bee Venom On Selected Pathogenic Bacteria

Document Type : Original Article

Authors

¹ Entomology Department, Faculty of Science, Ain Shams University

² Beekeeping, Agriculture Research Center, Giza

³ Clinical pathology Department, Faculty of medicine Al-Azhar University

⁴ Director of ANDI center of excellence in antivenom research, Vacsera, Egypt

⁵ Faculty of science Ain shams university

10.21608/eajbsg.2015.16487

Abstract

Honey
bee venom of Apis mellifera carnica with LD₅₀ equal to
290µg/mouse, was analyzed by HPLC (high performance liquid chromatography) to
perform its activity and found that it contains the most important active
compounds which are Melittin (52.1%), Phospholipase A2(11.9%), and Apamin (2.3%)
then tested against selected pathogenic bacteria invitro. The selected
bacteria were Methicillin resistant Staphylococcus aureus (MRSA), Proteus
sp., E.coli ,Salmonella sp., The results showed that bee venom has high
significant effect on Gram positive bacteria (MRSA), and from moderate to low
significance on gram negative bacteria (Proteus sp., E.coli ,
Salmonella sp.) therefore Bee venom could be a promising alternative
antibiotic

Keywords