Frequency of Multi-Drug Resistant Enterobacter Species Isolated from Patients with Different Clinical Manifestations in Khartoum State, Sudan

Mahgoub, Hiba Abdel Salam Ahmed; Mahgoub, Tyseer A.A.; Khair, Osama M. M.; Mohammed, Mawada H.F.; Merghani, Maye M.; AlBushra, Majdolin I.M.; Hamdan, Elsadig M.; Altyab, Hisham N.; Ahmed, Hind H.; Elhassan, Mogahid M.

doi:10.21608/eajbsg.2023.296702

Frequency of Multi-Drug Resistant Enterobacter Species Isolated from Patients with Different Clinical Manifestations in Khartoum State, Sudan

Document Type : Original Article

Authors

¹ Department of Medical Microbiology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan.

² Fetomaternal center-Doha-Qatar

³ National University Biomedical Institute, National University, Sudan. -Oczon Laboratory of Molecular Biology, Khartoum, Sudan.

⁴ Department of Medical Microbiology, Yastabshiroon Hospital, Sudan

⁵ Medical Laboratory Science program, AlNahda College, Sudan.

⁶ Department of Medical Microbiology, College of Medical Laboratory Science, University of Gezira, Sudan.

⁷ Department of Medical Microbiology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan -Biochemistry Department, Faculty of Sciences, King Abdulaziz University, Jeddah 21452, Saudi Arabia

⁸ Department of Medical Microbiology, College of Medical Laboratory Science, Sudan University of Science and Technology, Sudan-Nahrain College, Khartoum, Sudan.

10.21608/eajbsg.2023.296702

Abstract

Enterobacter species are members of ESKAPE (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species) which are described as the leading cause of resistant nosocomial infections.Objectives: The present study aimed to estimate the frequency of Multi-Drug resistant Enterobacter species isolated from Patients with different Clinical manifestations in Khartoum state, Sudan.Methods: A cross-sectional laboratory-based study was conducted from February 2021 to October 2021. To isolate and identify Enterobacter species from different clinical specimens by conventional cultural methods, and to determine the antimicrobial profile of Enterobacter species by Kirby–Bauer disc diffusion technique.Result: A total of three hundred and eighty-four (n=384) different clinical specimens (urine 232(60%), wound swab 61 (16%), sputum 19(5%), and blood 72 (19%) specimens were collected from Yastabshiroon Hospital, Khartoum, 129(33.6%), Ribat Teaching Hospital, Khartoum, 255(66.4%), 173 (45.0%) were from males, while 212 (55.0%) from females, among 154(40%) bacterial isolate 22(14.3%) were identified as Enterobacter spp. All Enterobacter spp isolates (100%) were multidrug resistant, The Prevalence rates of resistance of the isolates among antibiotic classes were as follows; (Penicillin 100%, Cephalosporin 96.4%, Tetracycline group 100%, Aminoglycosides 47.7%, Sulfonamides and trimethoprin 86.4%, Nitrofuran 100%, Quinolone 72.75%, Glycopeptides 100%, Chloramphnicol 100%, Tetracycline 81.8% and Carbapenem 52.3%).Conclusion: This study is the first study reporting the frequency of Multi-drug resistance Enterobacter species in Sudan. The results of this study indicated the high prevalence of Enterobacter species resistant to the majority of assessed antibiotics, and high prevalence rates of carbapenemase and ESBL-producing Enterobacter species In Khartoum- Sudan.

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